MS Stem-Cell Treatment ‘Successful’

Stem-cell transplants may control and even reverse multiple sclerosis symptoms if done early enough, a small study has suggested.

Not one of 21 adults with relapsing-remitting MS who had stem cells transplanted from their own bone marrow deteriorated over three years.

And 81% improved by at least one point on a scale of neurological disability, The Lancet Neurology reported.

Further tests are now planned, and a UK expert called the work “encouraging”.

MS is an autoimmune disease which affects about 85,000 people in the UK.

It is caused by a defect in the body’s immune system, which turns in on itself, causing damage to the nerves which can lead to symptoms including blurred vision, loss of balance and paralysis.

At first, the condition mostly causes intermittent symptoms that are partly reversible.

Over a 10-15 year period after onset, most patients develop secondary-progressive MS, with gradual but irreversible neurological impairment.

It is not the first time this treatment – known as autologous non-myeloablative haemopoietic stem-cell transplantation – has been tried in people with MS, but there has not been a great deal of success.

The researchers at Northwestern University School of Medicine in Chicago said most other studies had tried the transplants in people with secondary-progressive MS where the damage had already been done.

In the latest trial patients with earlier stage disease who, despite treatment had had two relapses in the past year, were offered the transplant.

Source: BBC News